Since day one I got the new Scarlett, I lose my audio at least 1 to 2 times a day. A quick re-connect always works, or making a subtle change like turning on or off the loopback feature works as well. A split second before the sound cuts out, I hear a quick faint static sound. There's been like 5 or so updates since I purchased it, still same issue. I've completely uninstalled 3rd gen software / drivers, and done all the other basic stuff. My 3rd Gen I tried for a few days, and it has no issues. For me it's hard to tell if it's hardware or software related.