Currently in NG+ Unmoored.

Doing some of the important side quests lines like Arbor village, Wilhrminas, Warfarer actually affect your ability to evacuate people.

In this cycle I did no side quests essentially

1. Arbor village just accepts their fate to die with the tree. Couldn't find elf sister, though she mightve either been eaten or just somewhere else in the village

2. Allard takes the oxcarts so people can't evacuate. Though you can actually kill him/scare him away in front of everyone, which the oxcart owner will mention.

3. Warfarer dude won't help at all and just accepts his fate to die at camp if you don't befriend him/refuse to help protect the evacuees.

Might be others but didn't bother looking too hard.