Bosses

Main article: Captain Vor

Captain Vor is the Grineer officer responsible for the players' awakening in the opening moments of WARFRAME. He is one of the few figures in the Origin System that understand ancient Orokin technology, and is capable of utilizing it and merging it with Grineer technology to create offensive weapons such as his trademark  Seer pistol and his armor, powered by a Void Key that he refers to as the "Janus Key," which also grants him a powerful ranged beam attack, impenetrable shielding and the ability to teleport.

Main article: Jackal

Jackal is the Corpus boss of the Venus system. Although a more bulky and old model compared to more recent Corpus robotics, the Jackal possesses invulnerable shields, a giant shockwave ability to knock players down, and one of the most powerful Corpus weapons, the Plasma Grenade Cluster. Dissected models of the Jackal can be found in some Grineer tilesets, either showing that the Grineer have an interest in utilizing Corpus tech, or that they have simply purchased merchandise. The Jackal is fought on the mission Fossa, Venus. After defeating it and finishing the mission, the player will receive  Rhino component blueprints, as well as a chance to get a  Stahlta or  Stropha blueprint.

A Terra variant may spawn in Orb Vallis during high alert state, which is considered a common enemy and will neither drop blueprints nor anger the Stalker. A Corrupted variant appears in The Circuit Assassination as a boss with some alteration to its mechanics.

Main article: Phorid

Phorid is an  Infested Boss only found when an Invasion takes over the Assassination mission of a Planet. After players defeat it and reach the extraction point, they will receive either a  Nyx Neuroptics, Chassis, or Systems blueprint upon mission completion. Upon death, Phorid has a chance of dropping rare resources of the planet it appears on.

Main article: Ropalolyst

The Ropalolyst is a gigantic bird-like Sentient boss capable of flight. It can be found in the Remastered Corpus Gas City on its own Assassination node on Jupiter, requiring players to have completed Chimera Prologue to battle it. It was dispatched by the Sentients to ensure Alad V does not double-cross their "partnership", much to his displeasure.

After defeating the Ropalolyst, the player will receive  Wisp component blueprints and an Amalgam mod from five possible.

Main article: Nihil

Nihil is a mysterious serial killer known as the Glassmaker, a former Orokin judge responsible for "glassing" people throughout the Origin System. He is also the creator of the Cephalons, which he designed to be an eternal punishment for those that dare break Orokin law. He was introduced during Nightwave: Series 3 - The Glassmaker.

Main article: The Fragmented

Main article: Ven'kra Tel

Ven'kra Tel is a special Grineer Field Boss unit first introduced in Operation Gate Crash and now regularly encountered in Orokin Sabotage missions where Grineer are the dominant enemy. She, along with Sprag, guard a Void Key necessary to close the Void Portal. She was later captured by Narmer and forced into their service.

She possesses a blue jet pack identical to that used by Hellions that grants her excellent mobility, and can use her Avex and other ranged special abilities to engage Tenno from afar.

Main article: Sprag

Sprag is a Grineer Field Boss unit first introduced in Operation Gate Crash and now regularly encountered in Orokin Sabotage missions where Grineer are the dominant enemy. She, along with Ven'kra Tel, guard a Void Key necessary to close the Void Portal. She is later captured by Narmer and forced into their service.

She possesses a jet pack identical to that used by Hellions that grants her excellent mobility, and can use her Renok Hammer and special melee abilities to engage Tenno in close combat.

Main article: Misery

Misery is one of Shadow Stalker's acolytes. He takes the form of  Nekros with an Immortal Skin, wearing Stalker's helmet and  Oberon's loincloth, as well as modified Warframe Cosmetics including a Kyroptera Syandana and Daedalus Chest Plate codpiece.

Misery first appeared in Operation: Shadow Debt and, as of Update 29.5 (2020-11-19), now spawns in The Steel Path missions.

Main article: Stalker

The Stalker is an ominous, vengeful figure that infrequently appears during missions, armed with powerful weapons and abilities to hunt down Tenno who have his Death Mark.

The Stalker is a sapient Warframe and is able to use ability powers belonging to various other Warframes. His arsenal is similar to that of the Tenno, utilizing a primary, secondary, and melee weapon. The Stalker's signature weapons are the bow  Dread, the scythe  Hate, and the throwing knives  Despair.

If the Tenno marked for assassination has completed The Second Dream Quest, they will be confronted with the more powerful, Sentient-enhanced Shadow Stalker instead. Upon completing the Jade Shadows Quest, Stalker will appear as Protector Stalker, having reverted to his original appearance, with his mask and  Hate imbued by  Jade's energies.

Main article: Eidolon Teralyst

The Eidolon Teralyst is a gigantic spectral Sentient Eidolon creature that can be found aimlessly roaming around the Plains of Eidolon at night, acting as one of the Grand Bosses of the landscape. This is the first of the 3 night bosses of Plains of Eidolon, followed by Eidolon Gantulyst and then Eidolon Hydrolyst.

The Eidolons are remnants of a massive Sentient that was defeated in a battle against the Tenno during the Old War, whose remains now wander the plains perpetually searching for their lost components. These fragments are, however, still formidable creatures armed with powerful attacks and near-impenetrable defenses, and are hostile to both Tenno and Grineer alike.

It is important to note players that have not unlocked Transference from The War Within won't have any means to properly fight the Bosses.

Main article: Profit-Taker Orb

Profit-Taker Orb is a large Raknoid creature found atop the Enrichment Labs in the Orb Vallis, acting as one of the Grand Bosses of the landscape. The gargantuan creature can only be engaged during the Heist with Vox Solaris, requiring the rank of Old Mate within Solaris United.

The orb incorporates Sentient technology within its shields that are put into overcharge by satellites and is protected by an extremely durable carapace reserved for Corpus Ships, making it seemingly invulnerable.

Main article: Kuva Lich/Main

Main article: Arn Etina

Arn Etina was once the name of the final boss of Pluto, a black MOA found on Hades. Upon death there was a chance he would drop one of the components required to build  Excalibur. Arn Etina's name was changed to Ambulas as of Update 6.0 (2013-01-29).

Despite being a MOA, Arn Etina used a human-like game picture for their transmissions. The game picture and appearance have since been repurposed for Darvo.