Release Date: December 22nd, 2016
Epitome of the endlessly evolving Infestation, Nidus bends the vile corruption to his will, mutates his genetic potency to adapt and assimilates his victims with an insatiable parasitic hunger. Nidus and his strain developed in Update 19.5 (2016-12-22).
Acquisition
Nidus' main blueprint is acquired from The Glast Gambit quest; additional main blueprints can be bought from Cephalon Simaris for
Item | Source | Chance | Expected | Nearly Guaranteed |
---|---|---|---|---|
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Infested Salvage / C | 14.29% | ~ 6 C Rotations | 44 ± 14 C Rotations |
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Infested Salvage / C | 14.29% | ~ 6 C Rotations | 44 ± 14 C Rotations |
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Infested Salvage / C | 14.29% | ~ 6 C Rotations | 44 ± 14 C Rotations |
All drop rates data is obtained from DE's official drop tables.
See Mission Rewards#Standard Missions for definitions on reward table rotations.
For more detailed definitions and information,
visit here.
Alternatively, upon completion of The Duviri Paradox, Nidus's main and component blueprints can be earned from The Circuit. By selecting him on the rotating week he is available, players can earn his blueprints after reaching Tier 2 (Neuroptics), 5 (Chassis), 8 (Systems), and 10 (Main) rewards.
Crafting
Manufacturing Requirements | |||||
---|---|---|---|---|---|
![]() 25,000 |
![]() 1 |
![]() 1 |
![]() 1 |
![]() 2,000 |
Time: 3 Day(s) |
Rush: ![]() | |||||
![]() ![]() |
|||||
Nidus Neuroptics Blueprint | |||||
![]() 15,000 |
![]() 10 |
![]() 2,600 |
![]() 1,000 |
![]() 3 |
Time: 12 Hour(s) |
Rush: ![]() | |||||
Nidus Chassis Blueprint | |||||
![]() 15,000 |
![]() 6,000 |
![]() 5,000 |
![]() 1,400 |
![]() 3 |
Time: 12 Hour(s) |
Rush: ![]() | |||||
Nidus Systems Blueprint | |||||
![]() 15,000 |
![]() 6,000 |
![]() 3,500 |
![]() 14 |
![]() 6 |
Time: 12 Hour(s) |
Rush: ![]() |
Lore
Little is known about the history of the Nidus Warframe aside from its Orokin era origins. However, the Myconians have apparently used information learned from their time possessing the relic, the Nidus blueprint, to produce the Triuna, an infection passed down from generation to generation, which the Infestation fears due to the hybrid nature of the resulting host, allowing the Myconians to harvest Infested flesh as part of their livelihood.
Nidus has a mysterious connection with the Helminth being that resides in the Orbiter, being the only Warframe that can purposely command the Helminth to infect him with the Helminth Virus; the extent of this relationship is currently unknown.
Notes

Nidus with 100 Mutation Stacks
- Nidus has unique interactions due to his lack of shields:
- The shield reduction from the Decaying Dragon Key has no effect, allowing Nidus to carry it without issue.
- The No Shields Nightmare Mode condition has no effect.
- Cryogenic Leakage has no effect on his nonexistent shields. His friction is still affected however.
- The increased shield damage from
Magnetic has no effect. Energy drain and HUD disruption still occurs however.
Rage and
Hunter Adrenaline will always give energy when damage is taken.
- The Hijack objective will drain his health instead in order to move.
- He cannot receive overshields, or gain shields from allied Shield Ospreys, Orokin Drones,
Hildryn's
Haven, or
Protea's
Grenade Fan.
- His lack of shields prevents him from receiving shield gating.
- Nidus can uniquely access the Orbiter's Helminth Infirmary without the Helminth Segment prerequisite. If he sits in the infirmary's chair, he will be injected with the "Helminth Virus", forming an Infested cyst on the left side of his neck after 24 hours and grows to full size after 7 days, while simultaneously "awakening" the Helminth which will begin to communicate to the Tenno. Nidus can also spread this virus to other players he comes into contact with in combat and in a Clan Dojo or Orbiter, causing the cyst to grow on their Warframe, and those Warframes can also further propagate the virus.
- The injection will only occur once, and will not happen again to additionally built Nidus. However, Nidus can still receive the cyst from another infected player.
- When entering the Helminth room, Nidus will automatically switch to his fully infested form (as he appears with 10 Mutation Stacks). As he leaves the room, he will revert to his normal appearance.
- Nidus' appearance changes as he accumulates Mutation Stacks:
- At 3 stacks, tendrils will protrude from his neck and upper spine, while the carapace around his ribs will open.
- At 5 and 7 stacks respectively, the carapace around his thighs and arms will open to reveal more infested flesh and tendrils beneath.
- At 10 stacks, the sides of his head extend outward to form a pair of horns, also exposing many more tendrils.
Trivia

Nidus infecting another Warframe
- The word nidus (Latin root: "nest") is defined as the site of origin for disease or bacteria or a place where bacteria multiplies.
- Nidus is the first Warframe to use
Kuva as a blueprint ingredient.
- Nidus is the second Warframe after
Inaros to have no base shields whatsoever.
- Nidus is also the first Warframe to use another type of ability resource besides energy, in the form of Mutation stacks.
- Nidus is the first and only Warframe to innately regenerate Health.
- Nidus is the first frame to have extra stat bonuses when leveling up.
- The screech of Nidus' fourth ability was done by Digital Extremes sound designer, Willem Schonken.[1]
Reference
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Upcoming | ||
Cyte-09 | ||
Attributes • Helminth • Augments • Compare All • Cosmetics |
794 comments
Hello, guess my name.
I am immortal, can give CC, can group enemies, can regen, can buff allies STR and HP, have built-in PSF & status immunity, and can regen health on myself and allies, I have good crowd control.
Despite all this, i am USELESS in almost every single mission (exception is : playing solo in survival missions).
Nidus?
How to fix Nidus:
1) Make his 3 a toggle, if it's on, you will automatically link to an ally or enemy nearby, this would allow you to move around the map without having to recast it all the time
2) Make his 4 scale with range, so you don't have to stand in a tiny area to get the health regen
3) Make his stacks have no limit, or at least raise the limit, at least 300 with no augment, more with augment
1) Actual clown idea. Mod for range or stop pretending you're playing Gauss/Volt and snapping your cables by running away from your links.
2) I agree. It would make it better for some tiles.
3) Actual clown idea. 100x-300x ability strength is enough for full SP star chart. If you think you need more then you need to play another frame.
The problem with Nidus is that he's really only got one game plan that isn't even compatible with most mission types.
It goes:
1: Start endless SP mission, either Defense or Survival
2: Group up a bunch of enemies with Larva and slam into them with Virulence over and over again to generate stacks
3: Pick a favourite spot
4: Link to an enemy
5: Cast Ravenous
6: Proceed to spam out Larva and Virulence, recast Link and Ravenous when they run out.
Nidus' entire kit basically forces him to hunker down in some corner and just murder everyone who comes at him. You wanna stay on Ravenous at all times for the extra health regen and you wanna be linked at all times for damage redirection and status immunity and both Ravenous and Link targets are stationary.
Also, he's basically useless outside of Steel Path because Mutation Stacks don't generate quick enough if you don't have extreme enemy density.
At the same time, if you lose your stacks in SP in any way, you're screwed. If you run into something that can munch through your healthbar too quickly and that you cannot yourself kill quickly, like the Oni from the Shrine defense gamemode, and that eats through your mutation stacks and immortalities until you actually die, there's no way for you to recover. Once things have picked up, you're taking damage way too quickly to get your stacks back since that basically involves standing still and stomping the ground repeatedly.
Stomp Ground
Gain Stacks
If there's one thing I want changed about Nidus it's why do his abilities have seemingly random lockouts?
If he's got a 1 cast traveling it becomes locked out until it finishes, so it's literally better to spam it into a wall so it travels less.
Man of Cancer
I've got two nidus frames and all i want to say how dead Nidus is unless you use him for obscure grinding
Nidus is nearly unkillable when built correctly.
Every frame is nearly unkillable when built correctly
does anyone know if Hunter Adrenaline and Rage still work?? or is that rewording they got curtains for them
Work
Both still work. Combine with Quick Thinking, Umbra Mods, and 5 Blue Archon Shards (+5 HP/s), and if possible... Arcane Grace, and Arcane Guardian. He'll be nearly unkillable.
Really din't knew what i was doing wrong before Parasitic vitality came to save my dumb ass from dying all the time, i just couldn't make nidus (before the augment) tanky without needing the damage reduction from parasitic link
Still haven't figured out to this day
His playstyle is quite niche, the best way to play him is to abuse his passive, but that pretty much locks him to endless missions and keeping maximum mutation stacks. Parasitic vitality is a great augment and makes for funny health numbers tho
At levelcap I literally ran him with the augment mod for his 4 to generate more than 15 mutation stacks in the 5 second window after dying, before dying again.
It did effectively make me completely invincible even with no defense investment.. but also made me do no damage because too busy casting 1 to shoot guns.
So what happens if you link to a mind controlled target? will it count as an ally or is it still considered an enemy?
Tested it, you cant link to it at all :/ i hate Parasitic Link
Buggy appearance. Every time you end a mission or look at your profile your nidus will switch to his full form and switch back immediately and when you aim he will look up.
Prime
My Nidus got injected with the virus but it is my Loki who got the cyst, I don't have the Helminth Segment, so Loki can't get there
No idea if this actually works but you can theoretically get a 4 and a half minute duration on Parasitic Link with all the duration mods and 5 Tauforged Crimson shards. Not sure why you'd want to but someone out there definitely does want to because funny numbers
Up until this moment, I never knew nidus had a prime, or that nidus even existed
I blame infested salvage.
Yup, that's among the most painful grinds imo
With Parasitic Vitality and Abundant Mutation + some strength from either mods, arcanes or Grimoire he can build full tank and survive lvl cap more easily without losing stacks.
Parasitic vitality + Abundant Mutation adds another 5x+ to ehp for my super tank build.
You could add Eclipse for even more max ehp+dmg or just Gloom.
For lvl cap I recommend Gloom for full auto heals (linked enemies in Gloom range auto-heal you when you take dmg).
Was able to face tank 9999 before without losing stacks, but now it is much, much more comfortable.
(Using all possible, conditional dmg reduction mods like Aviator, Adaptation, Arcane Double Back, 2x Boreal set mods, etc. and 5x Tau armor shards + Unairu)
So the new augment is interesting. Takes the place of normal vitality mods but much stronger with a caveat. Takes time and investment, but significantly improves nidus' durability in long missions.
Tested with his passive augment and around 270 power strength: Reached an hp level of 21k health.
It's also fun messing around with an Inaros teammate, giving them hp thus giving Scarabs more damage
I subsumed Tharros Strike over Ravenous so he has some kind of defense strip. Otherwise he isn't doing much in late game Grineer or Corrupted.
Just use Unairu for grineer. He has a gathering skill anyway
So, do maggots from ult apply corosive if using archon continuity?
The maggots only deal toxin damage, and not apply the toxin proc, so it does not.
Are there any downsides to linking to an ally?
Yes, you don't have the damage reduction
He looks so much cooler in prime form