The Void Relics for this item have been removed from the drop tables and do not drop during missions at this time. Check the current Prime Resurgence rotation to see if Varzia offers relics for this item. Vaulted Void Relics already contained in player inventories are not affected and can still be either opened or traded between players.
Mutation is endless. The ravening plague-bearer returns in a long-unseen form, seething with a primal strain of the Infestation. Features altered Mod polarities for greater customization.
We cast our shining child adrift on strange seas. For with time, these starless currents black as mourning may work a sea-change. And if, one grisly dawn, the skies should hurl you, herald-like, back to Earth, remind us, foundling, of what we immaculate ones have lost.
Nidus Prime is the Primed variant of Nidus, sporting enhanced Health, Energy, and Armor, as well as an additional polarity. He was released alongside the Strun Prime and the Magnus Prime.
On July 27th, 2023, Nidus Prime, along with Strun Prime and Magnus Prime, entered the Prime Vault and were retired from the reward tables. Any preexisting components or fully-built items will remain as is.
As with any other Prime Warframe, moving close to the location of an Orokin VoidDeath Orb will restore a pulse of 250 Energy to nearby allies, even if that Death Orb is inactive, destroyed, or non-present. This effect can only occur once per orb.
Nidus Prime's appearance changes as he accumulates Mutation Stacks:
At 3 stacks, black tendrils form on the left side of his face, as well as his entire left arm.
At 5 stacks, the tendrils extend to cover his chest and back.
At 7 stacks, the right side of his fleshy body becomes covered in a black mass, as the golden metallic spikes on his right arm protrude outward, while tendrils form on his lower body.
At 10 stacks, the tendrils extend to cover his entire face and thighs.
Virulence, Larva, Ravenous' Maggots and its Infested nests have unique models of Orokin design, appearing twisted and overtaken by Nidus' Infestation.
Maggot Prime visually resembles Excalibur Prime's default helmet.
Trivia
Nidus Prime was revealed during TennoCon 2021 on 17th July 2021. Players in the TennoCon Relay were granted an up-close look of his in-game model.
Nidus Prime's concept art was illustrated by Mike Brennan, the original designer of Nidus.
![WARFRAME Wiki](data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" width="500" height="500"><rect fill-opacity="0"/></svg>)
Nidus, sporting enhanced Health, Energy, and Armor, as well as an additional 
polarity. He was released alongside the 
Strun Prime and the 
Magnus Prime.
Blueprint
Lith N12 Rare (V)
Meso N13 Rare (V)
Neo N18 Rare (V)
Axi A14 Uncommon (V)
Orokin Cell
50
Market Price: 
Blueprints Price: N/A
Argon Crystal
Cryotic
Circuits
Nano Spores
Tellurium
Plastids
Polymer Bundle
Alloy Plate
Nitain Extract
Neurodes
Rubedo
Salvage![NidusIcon272](data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" width="31" height="32"><rect fill-opacity="0"/></svg>)
Nidus:
![Virulence130xWhite](data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" width="32" height="32"><rect fill-opacity="0"/></svg>)
Virulence, 
Excalibur Prime's default helmet.
Ash • 
Atlas • 
Banshee • 
Baruuk • 
Caliban • 
Chroma • 
Citrine • 
Dagath • 
Dante • 
Ember • 
Equinox • 
Excalibur (
Umbra) • 
Frost • 
Gara • 
Garuda • 
Gauss • 
Grendel • 
Gyre • 
Harrow • 
Hildryn • 
Hydroid • 
Inaros • 
Ivara • 
Jade • 
Khora • 
Koumei • 
Kullervo • 
Lavos • 
Limbo • 
Loki • 
Mag • 
Mesa • 
Mirage • 
Nekros • 
Nezha • 
Nova • 
Nyx • 
Oberon • 
Octavia • 
Protea • 
Qorvex • 
Revenant • 
Rhino • 
Saryn • 
Sevagoth • 
Styanax • 
Titania • 
Trinity • 
Valkyr • 
Vauban • 
Volt • 
Voruna • 
Wisp • 
Wukong • 
Xaku • 
Yareli • 
Zephyr
794 comments
Hello, guess my name.
I am immortal, can give CC, can group enemies, can regen, can buff allies STR and HP, have built-in PSF & status immunity, and can regen health on myself and allies, I have good crowd control.
Despite all this, i am USELESS in almost every single mission (exception is : playing solo in survival missions).
Nidus?
How to fix Nidus:
1) Make his 3 a toggle, if it's on, you will automatically link to an ally or enemy nearby, this would allow you to move around the map without having to recast it all the time
2) Make his 4 scale with range, so you don't have to stand in a tiny area to get the health regen
3) Make his stacks have no limit, or at least raise the limit, at least 300 with no augment, more with augment
1) Actual clown idea. Mod for range or stop pretending you're playing Gauss/Volt and snapping your cables by running away from your links.
2) I agree. It would make it better for some tiles.
3) Actual clown idea. 100x-300x ability strength is enough for full SP star chart. If you think you need more then you need to play another frame.
The problem with Nidus is that he's really only got one game plan that isn't even compatible with most mission types.
It goes:
1: Start endless SP mission, either Defense or Survival
2: Group up a bunch of enemies with Larva and slam into them with Virulence over and over again to generate stacks
3: Pick a favourite spot
4: Link to an enemy
5: Cast Ravenous
6: Proceed to spam out Larva and Virulence, recast Link and Ravenous when they run out.
Nidus' entire kit basically forces him to hunker down in some corner and just murder everyone who comes at him. You wanna stay on Ravenous at all times for the extra health regen and you wanna be linked at all times for damage redirection and status immunity and both Ravenous and Link targets are stationary.
Also, he's basically useless outside of Steel Path because Mutation Stacks don't generate quick enough if you don't have extreme enemy density.
At the same time, if you lose your stacks in SP in any way, you're screwed. If you run into something that can munch through your healthbar too quickly and that you cannot yourself kill quickly, like the Oni from the Shrine defense gamemode, and that eats through your mutation stacks and immortalities until you actually die, there's no way for you to recover. Once things have picked up, you're taking damage way too quickly to get your stacks back since that basically involves standing still and stomping the ground repeatedly.
Stomp Ground
Gain Stacks
If there's one thing I want changed about Nidus it's why do his abilities have seemingly random lockouts?
If he's got a 1 cast traveling it becomes locked out until it finishes, so it's literally better to spam it into a wall so it travels less.
Man of Cancer
I've got two nidus frames and all i want to say how dead Nidus is unless you use him for obscure grinding
Nidus is nearly unkillable when built correctly.
Every frame is nearly unkillable when built correctly
does anyone know if Hunter Adrenaline and Rage still work?? or is that rewording they got curtains for them
Work
Both still work. Combine with Quick Thinking, Umbra Mods, and 5 Blue Archon Shards (+5 HP/s), and if possible... Arcane Grace, and Arcane Guardian. He'll be nearly unkillable.
Really din't knew what i was doing wrong before Parasitic vitality came to save my dumb ass from dying all the time, i just couldn't make nidus (before the augment) tanky without needing the damage reduction from parasitic link
Still haven't figured out to this day
His playstyle is quite niche, the best way to play him is to abuse his passive, but that pretty much locks him to endless missions and keeping maximum mutation stacks. Parasitic vitality is a great augment and makes for funny health numbers tho
At levelcap I literally ran him with the augment mod for his 4 to generate more than 15 mutation stacks in the 5 second window after dying, before dying again.
It did effectively make me completely invincible even with no defense investment.. but also made me do no damage because too busy casting 1 to shoot guns.
So what happens if you link to a mind controlled target? will it count as an ally or is it still considered an enemy?
Tested it, you cant link to it at all :/ i hate Parasitic Link
Buggy appearance. Every time you end a mission or look at your profile your nidus will switch to his full form and switch back immediately and when you aim he will look up.
Prime
My Nidus got injected with the virus but it is my Loki who got the cyst, I don't have the Helminth Segment, so Loki can't get there
No idea if this actually works but you can theoretically get a 4 and a half minute duration on Parasitic Link with all the duration mods and 5 Tauforged Crimson shards. Not sure why you'd want to but someone out there definitely does want to because funny numbers
Up until this moment, I never knew nidus had a prime, or that nidus even existed
I blame infested salvage.
Yup, that's among the most painful grinds imo
With Parasitic Vitality and Abundant Mutation + some strength from either mods, arcanes or Grimoire he can build full tank and survive lvl cap more easily without losing stacks.
Parasitic vitality + Abundant Mutation adds another 5x+ to ehp for my super tank build.
You could add Eclipse for even more max ehp+dmg or just Gloom.
For lvl cap I recommend Gloom for full auto heals (linked enemies in Gloom range auto-heal you when you take dmg).
Was able to face tank 9999 before without losing stacks, but now it is much, much more comfortable.
(Using all possible, conditional dmg reduction mods like Aviator, Adaptation, Arcane Double Back, 2x Boreal set mods, etc. and 5x Tau armor shards + Unairu)
So the new augment is interesting. Takes the place of normal vitality mods but much stronger with a caveat. Takes time and investment, but significantly improves nidus' durability in long missions.
Tested with his passive augment and around 270 power strength: Reached an hp level of 21k health.
It's also fun messing around with an Inaros teammate, giving them hp thus giving Scarabs more damage
I subsumed Tharros Strike over Ravenous so he has some kind of defense strip. Otherwise he isn't doing much in late game Grineer or Corrupted.
Just use Unairu for grineer. He has a gathering skill anyway
So, do maggots from ult apply corosive if using archon continuity?
The maggots only deal toxin damage, and not apply the toxin proc, so it does not.
Are there any downsides to linking to an ally?
Yes, you don't have the damage reduction
He looks so much cooler in prime form